Protein vav1 (IPR028530)

Short name: Vav1

Overlapping homologous superfamilies


Family relationships



Vav protein family members are multiple domain proteins, including Vav from flies and Vav1/2/3 from mammals. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a compound domain having SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [PMID: 10713454, PMID: 16106078]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [PMID: 10781813, PMID: 23525006, PMID: 14607270].

This entry includes mammalian Vav1 and its homologues.

GO terms

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.