Protein kinase C and casein kinase substrate in neurons protein 1 (IPR028518)

Short name: PACSIN1

Overlapping homologous superfamilies

Family relationships



PACSIN1 (protein kinase C and casein kinase substrate in neurons protein 1, also known as SYNDAPIN1) belongs to the PACSIN family that contains a N-terminal F-BAR (FCH-BAR) domain and a C-terminal SH3 domain [PMID: 23236520]. There are three tissue-specific isoforms of PACSIN1 found in mammals: PACSIN11 is enriched in neurons, PACSIN12 is ubiquitously expressed, and PACSIN13 is found mainly in muscle [PMID: 23236520]. They are cytoplasmic phosphoproteins that play a role in vesicle formation and transport [PMID: 11179684].

PACSIN1 is upregulated upon differentiation into neuronal cells [PMID: 9746365]. The SH3 domain of PACSIN1 mediates activation of neural WASP (N-WASP), which is required to regulate actin polymerisation and is essential for proper neuromorphogenesis and cellular motility [PMID: 19846719]. Two phosphorylation sites within the F-BAR domain of PACSIN1 are used for membrane tubulation regulation [PMID: 22355135].

GO terms

Biological Process

GO:0007015 actin filament organization
GO:0048666 neuron development
GO:0097320 plasma membrane tubulation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.