Family

Sorbin and SH3 domain-containing protein 2 (IPR028516)

Short name: ArgBP2

Family relationships

None.

Description

Sorbin and SH3 domain-containing protein 2 (Sorbs2), also known as Arg/Abl-interacting protein 2 (ArgBP2), belongs to a family of adapter proteins containing two other members, Vinexin and CAP (c-Cbl associated protein)/Ponsin. It has an N-terminal sorbin homology (SoHo) domain and three C-terminal SH3 domain (Src homology domain 3) [PMID: 11937713]. ArgBP2 is implicated in the control of cell morphology and membrane protrusion necessary for cell migration [PMID: 19262174]. It interacts with the Arp2/3 activator WAVE1, the tyrosine phosphatase PTP-PEST, and the tyrosine kinase c-Abl [PMID: 19262174]. It plays an important role in regulating cancer cell migration, adhesion, and tumorigenicity [PMID: 18559503].

GO terms

Biological Process

GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0016477 cell migration

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER