Erythrocyte band 7 integral membrane protein (Stomatin) (IPR028515)

Short name: Stomatin

Overlapping homologous superfamilies

Family relationships

  • Stomatin family (IPR001972)
    • Erythrocyte band 7 integral membrane protein (Stomatin) (IPR028515)


Stomatin (also known as band 7 integral membrane protein or protein 7.2b) is a major erythrocyte membrane protein that is missing in red cells of overhydrated hereditary stomatocytosis patients [PMID: 9147127, PMID: 23219802]. The protein contains a single hydrophobic domain, close to the N terminus, and is phosphorylated [PMID: 9147127]. Stomatin interacts with various ion channels and modulates their activities [PMID: 22768083, PMID: 15471860]. The major interaction partners of stomatin are glucose transporter-1 (GLUT1), anion exchanger (band 3), and water channel (aquaporin-1). It may play a role as membrane-bound scaffolding protein modulating transport proteins [PMID: 23219802].

Stomatin is also expressed in mechanosensory neurons, where it may interact directly with transduction components, including cation channels [PMID: 15471860]. A second function of stomatin is to act as a cytoskeletal anchor. One possible example of this is its interaction with some anti-malarial drugs. Current opinion speculates that such drugs bind to high density lipoproteins in serum. The lipoproteins are delivered to erythrocytes, where they may interact with stomatin as a means of transfer to the intracellular parasite, via a pathway used for the uptake of exogenous phospholipid [PMID: 9088993].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.