E3 ubiquitin-protein ligase SH3RF2 (IPR028511)

Short name: SH3RF2

Overlapping homologous superfamilies


Family relationships



SH3RF2 is also called POSHER (POSH-eliminating RING protein) or HEPP1 (heart protein phosphatase 1-binding protein). It acts as an anti-apoptotic regulator of the JNK pathway by binding to and promoting the degradation of SH3RF1 (or POSH), a scaffold protein that is required for pro-apoptotic JNK activation [PMID: 22128169]. It may also play a role in cardiac functions together with protein phosphatase 1 [PMID: 19945436]. SH3RF2 contains an N-terminal RING finger domain and three SH3 domains.

GO terms

Biological Process

GO:0046328 regulation of JNK cascade

Molecular Function

GO:0061630 ubiquitin protein ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.