Sorbin and SH3 domain-containing protein (IPR028506)

Short name: Sorbin_SH3

Overlapping homologous superfamilies


Family relationships



Sorbin and SH3 domain-containing protein 1 (Sorbs1, also known as c-Cbl associated protein, CAP or ponsin) and 2 (Sorbs2, ArgBP2) belong to a family of adaptor proteins that also contain vinexin [PMID: 11937713]. They have an N-terminal sorbin homology (SoHo) domain and three C-terminal SH3 domains (Src homology domain 3) [PMID: 11937713].

CAP has been implicated in insulin signalling and is required for insulin-stimulated glucose transport [PMID: 11001060]. It binds to the major endocytic factor dynamin and affects the actin cytoskeleton organisation [PMID: 19116150].

ArgBP2 is implicated in the control of cell morphology and membrane protrusion necessary for cell migration [PMID: 19262174]. It interacts with the Arp2/3 activator WAVE1, the tyrosine phosphatase PTP-PEST, and the tyrosine kinase c-Abl [PMID: 19262174]. It plays an important role in regulating cancer cell migration, adhesion, and tumorigenicity [PMID: 18559503].

GO terms

Biological Process

GO:0007015 actin filament organization

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.