E3 ubiquitin-protein ligase SH3RF1 (IPR028502)

Short name: SH3RF1

Overlapping homologous superfamilies


Family relationships



Plenty of SH3 domains protein 1 (POSH1, also known as POSH or E3 ubiquitin-protein ligase SH3RF1) is an SH3 domain containing protein that has been shown to act as an E3 ubiquitin ligase [PMID: 19710010]. It belongs to the POSH family, which includes POSH1, POSH2 and POSH3 [PMID: 20696164]. It contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis [PMID: 16230351]. It plays an essential role in the targeting of HIV-1 Gag to the plasma membrane [PMID: 15659549].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0046328 regulation of JNK cascade

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.