Endophilin-A (IPR028501)

Short name: Endophilin-A

Overlapping homologous superfamilies


Family relationships



Endophilin is a family of the BAR and SH3 (Src homology 3) domain-containing protein. In mammals the endophilins comprise endophilins A1, A2, A3 and B [PMID: 15363893]. This entry represents Endophilin-A from Drosophila and A1/A2/A3 from vertebrates.

In Drosophila, endophilin-A is required presynaptically at the neuromuscular junction and is implicated in synaptic vesicle endocytosis [PMID: 11955450, PMID: 11927550].

Endophilin-A1/2/3 are implicated in endocytosis. Endophilin-A3 forms filamentous structures that co-localise with microtubules but not with actin filaments [PMID: 15363893, PMID: 15066995].

GO terms

Biological Process

GO:0006897 endocytosis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.