Protein S100-A11 (IPR028482)

Short name: S100A11

Overlapping homologous superfamilies

Family relationships



S100A11 belongs to the S100 calcium-binding family. S100A11 has several biological functions. It is a ligand of RAGE (receptor for advanced glycation end products) and may be involved in the process of low-grade inflammation to osteoarthritis progression [PMID: 16339570]. S100A11 is a dual mediator for growth regulation in human keratinocytes [PMID: 17978094]. It binds to annexin I and plays a critical role in regulating growth of normal and malignant squamous epithelial cells [PMID: 17932043]. S100A11 could inhibit actin-activated myosin ATPase activity by binding to actin in the presence of Ca2+ [PMID: 10623577].

GO terms

Biological Process

GO:0042127 regulation of cell population proliferation

Molecular Function

GO:0005509 calcium ion binding
GO:0048306 calcium-dependent protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.