Family

Eyes absent homologue 3 (IPR028479)

Short name: EYA3

Overlapping homologous superfamilies

None.

Family relationships

Description

Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [PMID: 14628053, PMID: 17341163], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage [PMID: 19234442]. EYA proteins (EYA1-4) are normally expressed early in development [PMID: 9020840, PMID: 9887327]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [PMID: 14628042].

EYA3 forms a complex with Six1 and Ski that regulates muscle terminal differentiation [PMID: 19008232].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004725 protein tyrosine phosphatase activity

Cellular Component

GO:0005667 transcription factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER