Eyes absent homologue 4 (IPR028478)

Short name: EYA4

Overlapping homologous superfamilies


Family relationships


Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [PMID: 14628053, PMID: 17341163], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage [PMID: 19234442]. EYA proteins (EYA1-4) are normally expressed early in development [PMID: 9020840, PMID: 9887327]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [PMID: 14628042].

EYA4 is also important post-developmentally. Mutations in EYA4 can cause late-onset deafness and cardiomyopathy [PMID: 11159937, PMID: 15735644].

GO terms

Biological Process

GO:0007605 sensory perception of sound

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.