Protein S100-A9 (IPR028475)

Short name: S100-A9

Overlapping homologous superfamilies

Family relationships



S100A9 (also known as MRP-126 or calgranulin B) belongs to the S100 calcium-binding family and plays a prominent role in the regulation of inflammatory processes and immune response [PMID: 12626582]. S100A8 forms a heterocomplex with S100A9, termed S100A8/A9 or calprotectin. The intracellular functions of S100A8/A9 include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase [PMID: 22095980, PMID: 22489132, PMID: 12626582, PMID: 15642721]. The extracellular functions of S100A8/A9 involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities [PMID: 16258195, PMID: 8423249]. S100A8 and S100A9 may also have distinct functions and are regulated in part by different mechanisms [PMID: 19935766].

GO terms

Biological Process

GO:0045087 innate immune response
GO:0050727 regulation of inflammatory response

Molecular Function

GO:0050786 RAGE receptor binding
GO:0035662 Toll-like receptor 4 binding
GO:0050544 arachidonic acid binding
GO:0005509 calcium ion binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.