Protein S100-A8 (IPR028474)
Short name: S100A8
Overlapping homologous superfamilies
- EF-hand domain pair (IPR011992)
S100-A8 (also known as calgranulin A) belongs to the S100 calcium-binding family and plays a prominent role in the regulation of inflammatory processes and immune response [PMID: 12626582]. S100A8 forms a heterocomplex with S100A9, termed S100A8/A9 or calprotectin. The intracellular functions of S100A8/A9 include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase [PMID: 22095980, PMID: 22489132, PMID: 12626582, PMID: 15642721]. The extracellular functions of S100A8/A9 involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities [PMID: 16258195, PMID: 8423249]. S100A8 and S100A9 may also have distinct functions and are regulated in part by different mechanisms [PMID: 19935766].
No terms assigned in this category.
- PTHR11639:SF5 (PTHR11639:SF5)