Family

Eyes absent homologue 2 (IPR028473)

Short name: EYA2

Overlapping homologous superfamilies

None.

Family relationships

Description

Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [PMID: 14628053, PMID: 17341163], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage [PMID: 19234442]. EYA proteins (EYA1-4) are normally expressed early in development [PMID: 9020840, PMID: 9887327]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [PMID: 14628042].

EYA2 plays an important role in hypaxial muscle development together with Six1 and Dach2; in this it is functionally redundant with EYA1 [PMID: 17098221]. EYA2 is a necessary co-factor for many of the metastasis promoting functions of Six1 [PMID: 21706047].

GO terms

Biological Process

GO:0014706 striated muscle tissue development

Molecular Function

GO:0004725 protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER