Eyes absent homologue 2 (IPR028473)

Short name: EYA2

Overlapping homologous superfamilies


Family relationships


Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [PMID: 14628053, PMID: 17341163], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage [PMID: 19234442]. EYA proteins (EYA1-4) are normally expressed early in development [PMID: 9020840, PMID: 9887327]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [PMID: 14628042].

EYA2 plays an important role in hypaxial muscle development together with Six1 and Dach2; in this it is functionally redundant with EYA1 [PMID: 17098221]. EYA2 is a necessary co-factor for many of the metastasis promoting functions of Six1 [PMID: 21706047].

GO terms

Biological Process

GO:0014706 striated muscle tissue development

Molecular Function

GO:0004725 protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.