Family

Eyes absent homologue 1 (IPR028471)

Short name: Eyes_absent_h1

Overlapping homologous superfamilies

None.

Family relationships

Description

Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [PMID: 14628053, PMID: 17341163], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage [PMID: 19234442]. EYA proteins (EYA1-4) are normally expressed early in development [PMID: 9020840, PMID: 9887327]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [PMID: 14628042].

EYA1 may have a role in the development of the components of the inner ear, the kidney [PMID: 12701758, PMID: 10471511], and in eye morphogenesis [PMID: 10655545].

GO terms

Biological Process

GO:0009887 animal organ morphogenesis
GO:0042471 ear morphogenesis
GO:0035335 peptidyl-tyrosine dephosphorylation

Molecular Function

GO:0004725 protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER