Eyes absent homologue 1 (IPR028471)

Short name: Eyes_absent_h1

Overlapping homologous superfamilies


Family relationships


Members of the eye absent (EYA) family were originally characterised in fly eye development. EYA proteins are both transcriptional activators and tyrosine phosphatases [PMID: 14628053, PMID: 17341163], and have been shown to dephosphorylate H2AX, promoting repair and cell survival in the response to DNA damage [PMID: 19234442]. EYA proteins (EYA1-4) are normally expressed early in development [PMID: 9020840, PMID: 9887327]. Their phosphatase activity regulates Six1-Dach-Eya transcriptional effects in precursor cell proliferation and survival in mammalian organogenesis [PMID: 14628042].

EYA1 may have a role in the development of the components of the inner ear, the kidney [PMID: 12701758, PMID: 10471511], and in eye morphogenesis [PMID: 10655545].

GO terms

Biological Process

GO:0009887 animal organ morphogenesis
GO:0042471 ear morphogenesis
GO:0035335 peptidyl-tyrosine dephosphorylation

Molecular Function

GO:0004725 protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.