Interleukin-8 (IPR028469)

Short name: Interleukin-8

Overlapping homologous superfamilies

Family relationships


The accumulation of neutrophil leukocytes in tissues is a major event in inflammation, a defensive reaction in response to injury or infection [PMID: 1639201]. Neutrophils are drawn in from the blood by chemotactic signals that direct their migration to the affected site. Interleukin-8 (IL8) is one such chemotactic protein: it is released by phagocytes, mesenchymal cells and a wide variety of tissue cells, upon exposure to inflammation; and it acts as a neutrophil-activating cytokine, inducing chemotaxis, exocytosis, and the respiratory burst.

IL-8 is a member of the CXC chemokine family. It attracts neutrophils, basophils, and T-cells, but not monocytes.

GO terms

Biological Process

GO:0042119 neutrophil activation
GO:0030593 neutrophil chemotaxis

Molecular Function

GO:0008009 chemokine activity
GO:0005153 interleukin-8 receptor binding

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.