Family

DNA topoisomerase II-beta (IPR028467)

Short name: Top2b

Family relationships

Description

DNA topoisomerase II (TOP2) makes double-strand breaks and is essential during mitosis and meiosis for proper segregation of daughter chromosomes [PMID: 1331984]. TOP2 can produce DSB implicated in the pathogenesis of rearrangements in treatment related acute myeloid leukemia (t-AML) and childhood leukemias [PMID: 20601956]. Mammalian cells encode two type II isozymes, topoisomerase II alpha (TOP2a) and beta (TOP2b), that have highly identical N-terminal ATPase and central core domains. However, they differ in their C-termini as well as expression patterns and cannot compensate for each other [PMID: 15456904].

This entry represents DNA topoisomerase 2-beta.

GO terms

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0008301 DNA binding, bending
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER