DNA topoisomerase II-alpha (IPR028466)

Short name: Top2a

Family relationships


DNA topoisomerase II makes double-strand breaks and is essential during mitosis and meiosis for proper segregation of daughter chromosomes [PMID: 1331984]. Mammalian cells encode two type II isozymes, topoisomerase II alpha (TOP2a) and beta (TOP2b), that have highly identical N-terminal ATPase and central core domains. However, they differ in their C-termini as well as expression patterns and cannot compensate for each other [PMID: 15456904].

This entry represents TOP2a, which is associated with replication forks and remains tightly bound to chromosomes during mitosis. It is essential for the survival of proliferating cells and may functions in DNA replication and chromosome segregation [PMID: 19042970].

GO terms

Biological Process

GO:0006265 DNA topological change

Molecular Function

GO:0008301 DNA binding, bending
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0000287 magnesium ion binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.