Tyramine beta-hydroxylase/Dopamine beta-hydroxylase (IPR028460)

Short name: Tbh/DBH

Overlapping homologous superfamilies


Family relationships


This entry includes tyramine beta-hydroxylases from invertebrates and dopamine beta-hydroxylases from mammals.

Tyramine beta-hydroxylase (TBH) converts tyramine into octopamine, a neurotransmitter involved in pharyngeal pumping and egg laying in Caenorhabditis elegans [PMID: 15848803] and in ovulation and locomotion in Drosophila [PMID: 8656284, PMID: 14623230, PMID: 14978721]. It is evolutionarily related and remarkably similar to mammalian dopamine beta-hydroxylase [PMID: 8656284].

Dopamine beta-hydroxylases (DBH) converts dopamine to noradrenaline (norepinephrine), a key neurotransmitter of the central and peripheral nervous systems [PMID: 6998654, PMID: 11857564]. DBH is a copper-containing oxygenase consisting of four identical subunits. Mutations in DBH gene cause the dopamine beta-hydroxylase deficiency (DBH deficiency), which is characterised by profound deficits in autonomic and cardiovascular function [PMID: 20301647].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.