ABI family (IPR028457)

Short name: ABI

Overlapping homologous superfamilies


Family relationships


This entry represents the ABI family, which includes Abi1, Abi2 and Abi3. They are SH3 domain-containing proteins that are involved in regulation of actin organisation. Abi1, Abi2 and Abi3 all participate in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [PMID: 21482783, PMID: 11516653, PMID: 17101133]. This entry also include Abl interactor homologue (abiA) from Dictyostelium discoideum (Slime mold). abiA is part of a Scar/WAVE complex that is required for proper cytokinesis [PMID: 18261908].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.