Family

Abl interactor 1/2 (IPR028456)

Short name: ABI1/ABI2

Family relationships

  • ABI family (IPR028457)
    • Abl interactor 1/2 (IPR028456)

Description

Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for cytoskeletal reorganization [PMID: 11516653]. Abi1 and Abi2 play an important role in actin cytoskeleton dynamics through participation in several multiprotein complexes. They participate in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [PMID: 21482783, PMID: 11516653, PMID: 17101133].

Abi1 promotes tyrosine phosphorylation of mammalian enabled (Mena) by c-Abl kinase [PMID: 12672821]. It is essential for WAVE2 complex integrity and embryonic survival in mice [PMID: 21482783]. Abi1 and the p85 regulatory subunit of PI-3 kinase may be the link between actin cytoskeleton remodelling and growth receptor signalling [PMID: 22617151].

Abi2 is a component of the WAVE1 complex. It localises to sites of actin polymerisation at the tips of lamellipodia and filopodia [PMID: 11516653]. Its structure has been solved [PMID: 21107423].

GO terms

Biological Process

GO:0008154 actin polymerization or depolymerization

Molecular Function

GO:0030296 protein tyrosine kinase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER