Abl interactor 1 (IPR028456)
Short name: ABI1
Overlapping homologous superfamilies
- ABI family (IPR028457)
- Abl interactor 1 (IPR028456)
Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for cytoskeletal reorganization [PMID: 11516653]. Abi1 and Abi2 play an important role in actin cytoskeleton dynamics through participation in several multiprotein complexes. They participate in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [PMID: 21482783, PMID: 11516653, PMID: 17101133].
Abi1 promotes tyrosine phosphorylation of mammalian enabled (Mena) by c-Abl kinase [PMID: 12672821]. It is essential for WAVE2 complex integrity and embryonic survival in mice [PMID: 21482783]. Abi1 and the p85 regulatory subunit of PI-3 kinase may be the link between actin cytoskeleton remodelling and growth receptor signalling [PMID: 22617151].
- PTHR10460:SF2 (PTHR10460:SF2)