14kDa phosphohistidine phosphatase (IPR028441)

Short name: PHPT1

Overlapping homologous superfamilies

Family relationships

  • Janus (IPR007702)
    • 14kDa phosphohistidine phosphatase (IPR028441)


14 kDa phosphohistidine phosphatase is a histidine phosphatase that may play a role of reversible histidine phosphorylation in neuronal functions [PMID: 12468887]. It may also have a role in regulating glucose and mitochondrial fuel-induced insulin secretion in pancreatic beta-cells [PMID: 20501872].

GO terms

Biological Process

GO:0035971 peptidyl-histidine dephosphorylation

Molecular Function

GO:0101006 protein histidine phosphatase activity

Cellular Component

GO:0005829 cytosol

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.