Family

Transcription factor TRPS1 (IPR028440)

Short name: TRPS1

Family relationships

None.

Description

The TRPS1 gene encodes a multi zinc-finger nuclear regulator of chondrocyte proliferation and differentiation [PMID: 23691375]. Mutations in the gene cause trichorhinophalangeal syndrome (TRPS), an autosomal dominant skeletal dysplasia [PMID: 14560312]. The Trps1 protein also acts as regulator of histone deacetylation, interacting with two histone deacetylases, Hdac1 and Hdac4, thereby increasing their activity [PMID: 23892436].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003700 transcription factor activity, sequence-specific DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER