Drebrin (IPR028438)

Short name: Drebrin

Overlapping homologous superfamilies


Family relationships



Drebrin is an actin binding protein that plays a key role in actin organisation. The interaction between drebrin and microtubule-binding +TIP protein EB3 links dynamic microtubules to actin filaments and is required for neuritogenesis [PMID: 18806788]. The F-actin-bundling activity of drebrin can be regulated by Cdk5 phosphorylation [PMID: 23979715]. In mammals, drebrin is highly expressed in growth cones of developing neurons and in dendritic spines of mature neurons [PMID: 20183806]. Loss of drebrin has been linked to memory loss in patients with Down syndrome/Alzheimer's [PMID: 22715045, PMID: 12009525].

GO terms

Biological Process

GO:0007015 actin filament organization

Molecular Function

GO:0003779 actin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.