Short name: Plakophilin-3
Overlapping homologous superfamilies
- Plakophilin/Delta catenin (IPR028435)
- Plakophilin-3 (IPR028434)
Armadillo repeat proteins mediate protein-protein interactions in diverse cellular processes. Plakophilins are members of the armadillo multigene family. They are essential components of the desmosomal plaque (a cell structure specialised for cell-to-cell adhesion), where they interact with desmosomal cadherins as well as the cytoskeletal linker desmoplakin [PMID: 16765467].
Like plakophilin-1 and -2, plakophilin-3 displays a dual intracellular location. Plakophilin-3 is present in nuclei and desmosomes of epithelial cells, suggesting involvement in both desmosome-dependent adhesion and signaling pathways [PMID: 10381383].
- PTHR10372:SF1 (PTHR10372:SF1)