Peptide methionine sulfoxide reductase (IPR028427)

Short name: Met_Sox_Rdtase

Overlapping homologous superfamilies

Family relationships



The oxidation of methionine residues in proteins is considered to be one of the consequences of oxidative damage to cells, which in many cases leads to the loss of biological activity. Peptide methionine sulphoxide reductase (Msr) reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulphoxide, (MetO), to methionine [PMID: 10841552]. Methionine (Met) can be oxidised to the R and S diastereomers of methionine sulfoxide (MetO). Methionine sulfoxide reductases A (MsrA) and B (MsrB) reduce MetO back to Met in a stereospecific manner, acting on the S and R forms, respectively. Msr is present in most living organisms [PMID: 8994848, PMID: 8816789].

Many bacteria, particularly pathogens, possess methionine sulfoxide reductase MsrA and MsrB as a fusion form (MsrAB) [PMID: 27551953]. This entry includes MsrB and the fusion form of these enzymes.

GO terms

Biological Process

GO:0030091 protein repair
GO:0006979 response to oxidative stress

Molecular Function

GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.