Hypermethylated in cancer 1 protein (IPR028424)

Short name: HIC1

Overlapping homologous superfamilies


Family relationships



Hypermethylated in cancer 1 (HIC1) is a transcriptional repressor that modulates P53-dependent and E2F1-dependent cell growth control and is epigenetically inactivated in various human cancers [PMID: 20154726]. It recognises and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' [PMID: 15231840]. It is a direct transcriptional repressor of ephrin-A1 and CXCR7, which are implicated in the pathogenesis of different cancers [PMID: 20154726, PMID: 19525223]. HIC1 is also involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses [PMID: 17213307, PMID: 16269335]. HIC1 interacts with several different corepressors such as CTBP1, CTBP2 and MTA1 (a subunit of the NuRD complex) [PMID: 20547755].

GO terms

Biological Process

GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0000122 negative regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.