Family

Suppressor of cytokine signalling 2 (IPR028410)

Short name: SOCS2

Family relationships

None.

Description

Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. They have been implicated in the negative regulation of several pathways, particularly the JAK/STAT pathway. SOCS2 is necessary for normal growth regulation [PMID: 12645661]. It appears to be a negative regulator in the growth hormone/IGF1 signaling pathway [PMID: 9727029, PMID: 12552091].

GO terms

Biological Process

GO:0046426 negative regulation of JAK-STAT cascade
GO:0001558 regulation of cell growth

Molecular Function

GO:0008269 JAK pathway signal transduction adaptor activity
GO:0005159 insulin-like growth factor receptor binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER