1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (IPR028395)

Short name: PLC-zeta1

Overlapping homologous superfamilies

Family relationships


Phosphoinositide-specific phospholipase C (PI-PLC), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, plays a role in the inositol phospholipid signaling by hydrolysing phosphatidylinositol-4,5-bisphosphate to produce the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These cause the increase of intracellular calcium concentration and the activation of protein kinase C (PKC), respectively.

The PLC family in murine or human species is comprised of multiple subtypes. On the basis of their structure, they have been divided into five classes, beta (beta-1, 2, 3 and 4), gamma (gamma-1 and 2), delta (delta-1, 3 and 4), epsilon, zeta, and eta types [PMID: 15140260, PMID: 15702972].

PLC-zeta is a sperm-specific isoform of PLC that triggers Ca2+ oscillations and egg activation [PMID: 12416999, PMID: 12117804, PMID: 15047934, PMID: 18322275]. This entry represents PLC-zeta-1.

GO terms

Biological Process

GO:0006816 calcium ion transport
GO:0007343 egg activation

Molecular Function

GO:0004629 phospholipase C activity

Cellular Component

GO:0005829 cytosol

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.