Family

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (IPR028390)

Short name: PLC-beta3

Family relationships

Description

Phosphoinositide-specific phospholipase C (PI-PLC), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, plays a role in the inositol phospholipid signaling by hydrolysing phosphatidylinositol-4,5-bisphosphate to produce the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These cause the increase of intracellular calcium concentration and the activation of protein kinase C (PKC), respectively.

The PLC family in murine or human species is comprised of multiple subtypes. On the basis of their structure, they have been divided into five classes, beta (beta-1, 2, 3 and 4), gamma (gamma-1 and 2), delta (delta-1, 3 and 4), epsilon, zeta, and eta types [PMID: 15140260, PMID: 15702972].

PLC-beta3 interacts with Shank2 and regulates mGluR-mediated calcium signal in the postsynaptic density region of neuronal synapses [PMID: 15632121].

GO terms

Biological Process

GO:0007268 synaptic transmission

Molecular Function

GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER