1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (IPR028387)

Short name: PLC-delta4

Overlapping homologous superfamilies


Family relationships


Phosphoinositide-specific phospholipase C (PI-PLC), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, plays a role in the inositol phospholipid signaling by hydrolysing phosphatidylinositol-4,5-bisphosphate to produce the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These cause the increase of intracellular calcium concentration and the activation of protein kinase C (PKC), respectively.

The PLC family in murine or human species is comprised of multiple subtypes. On the basis of their structure, they have been divided into five classes, beta (beta-1, 2, 3 and 4), gamma (gamma-1 and 2), delta (delta-1, 3 and 4), epsilon, zeta, and eta types [PMID: 15140260, PMID: 15702972].

Phospholipase C delta-4 overexpression upregulates the Erk signaling pathway and proliferation [PMID: 15140260]. It is required for acrosome reaction in sperm during fertilisation, probably by acting as an important enzyme for intracellular Ca2+ mobilisation in the zona pellucida-induced acrosome reaction [PMID: 11340203, PMID: 12695499]. It modulates the liver regeneration in cooperation with nuclear PKC [PMID: 16998201].

GO terms

Biological Process

GO:0007340 acrosome reaction
GO:0046488 phosphatidylinositol metabolic process
GO:0007165 signal transduction

Molecular Function

GO:0004629 phospholipase C activity

Cellular Component

GO:0005622 intracellular

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.