Pathways & interactions
Inactive phospholipase C-like protein 1/2 (IPR028382)
Short name: PLCL1/PLCL2
Overlapping homologous superfamilies
- Phosphoinositide phospholipase C family (IPR001192)
- Inactive phospholipase C-like protein 1/2 (IPR028382)
A group of phospholipase C-related, catalytically inactive proteins have been identified as novel inositol 1,4,5-trisphosphate binding proteins with a domain organisation similar to phospholipase C-delta, but lacking the enzymatic activity. These inactive phospholipase C-like (PLCL) proteins consists of at least two types of proteins (PLCL-1 and PLCL2).
Inactive phospholipase C-like protein 1 is an inositol 1,4,5-trisphosphate binding protein with a domain organisation similar to phospholipase C-delta, but lacking the enzymatic activity. It is involved in inositol phospholipid-based intracellular signaling and it is essential for the function of GABA(A) receptors [PMID: 10861248, PMID: 11867528].
Similar to PLCL-1, PLCL-2 may be involved in both inositol 1,4,5-trisphosphate-mediated and gamma-amino butyric acid-related signaling [PMID: 12467885].
- PTHR10336:SF84 (PTHR10336:SF84)