Family

Inactive phospholipase C-like protein 1/2 (IPR028382)

Short name: PLCL1/PLCL2

Overlapping homologous superfamilies

Family relationships

Description

A group of phospholipase C-related, catalytically inactive proteins have been identified as novel inositol 1,4,5-trisphosphate binding proteins with a domain organisation similar to phospholipase C-delta, but lacking the enzymatic activity. These inactive phospholipase C-like (PLCL) proteins consists of at least two types of proteins (PLCL-1 and PLCL2).

Inactive phospholipase C-like protein 1 is an inositol 1,4,5-trisphosphate binding protein with a domain organisation similar to phospholipase C-delta, but lacking the enzymatic activity. It is involved in inositol phospholipid-based intracellular signaling and it is essential for the function of GABA(A) receptors [PMID: 10861248, PMID: 11867528].

Similar to PLCL-1, PLCL-2 may be involved in both inositol 1,4,5-trisphosphate-mediated and gamma-amino butyric acid-related signaling [PMID: 12467885].

GO terms

Biological Process

GO:0035556 intracellular signal transduction
GO:0032228 regulation of synaptic transmission, GABAergic

Molecular Function

GO:0050811 GABA receptor binding
GO:0070679 inositol 1,4,5 trisphosphate binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER