1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (IPR028381)

Short name: PLC-gamma2

Overlapping homologous superfamilies


Family relationships


Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [PMID: 20807769].

There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage [PMID: 11602179]. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets.

This entry represents PLCg2. Mutations in PLCg2 gene cause familial cold autoinflammatory syndrome 3 (FCAS3), whcih is an autosomal dominant immune disorder charactersed by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure [PMID: 22236196]. Mutations in PLCg2 gene also cause autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID), which is an autosomal dominant systemic disorder characterised by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues [PMID: 23000145].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0004435 phosphatidylinositol phospholipase C activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.