Ski-related oncogene Sno (IPR028373)

Short name: Ski-rel_Sno

Overlapping homologous superfamilies


Family relationships


Ski-like protein or ski-related oncogene Sno may have regulatory role in cell division or differentiation in response to extracellular signals [PMID: 9207045, PMID: 11312113]. Four isoforms of the Sno protein have been identified, with the longest isoform known as SnoN. SnoN, as part of a histone deacetylase complex, binds to Smad proteins and blocks its ability to transduce TGF-beta signals [PMID: 15221015, PMID: 18537639, PMID: 10531062].

GO terms

Biological Process

GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway

Molecular Function

GO:0046332 SMAD binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.