Ribosomal protein L1/ribosomal biogenesis protein (IPR028364)

Short name: Ribosomal_L1/biogenesis

Overlapping homologous superfamilies

Family relationships


Ribosomal protein L1 is the largest protein from the large ribosomal subunit. The L1 protein contains two domains: 2-layer alpha/beta domain and a 3-layer alpha/beta domain (interrupts the first domain). The two domains cycle between open and closed conformations via a hinge motion. In Escherichia coli, L1 is known to bind to the 23S rRNA. The RNA-binding site of L1 is highly conserved, with both mRNA and rRNA binding the same binding site. Like several other large ribosomal subunit proteins, L1 displays RNA chaperone activity [PMID: 17517772,PMID: 15659579,PMID: 16330048,PMID: 12037305, PMID: 10801481,PMID: 12514741]. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [PMID: 8635468, PMID: 8607874], groups:

  • Eubacterial L1
  • Algal and plant chloroplast L1
  • Cyanelle L1
  • Archaebacterial L1
  • Vertebrate L10A
  • Yeast Utp30, Rpl1a, Rpl1b and Mrpl1.

This entry also matches ribosome biogenesis proteins, such as Cic1, which associates with the proteasome and is required for the degradation of specific substrates [PMID: 11500370], and for the synthesis of 60S ribosome subunits [PMID: 14623999].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.