GPI-anchor transamidase (IPR028361)

Short name: GPI_transamidase

Overlapping homologous superfamilies


Family relationships


Many glycoproteins of lower and higher eukaryotes are attached to the plasma membrane by means of a glycosylphosphatidylinositol (GPI) anchor, which is added onto newly synthesized proteins in the endoplasmic reticulum (ER). Precursors of GPI anchored proteins have a GPI anchoring signal at their C terminus; GPI-anchor transamidase (MEROPS identifier C13.005) removes the C-terminal peptide and replaces it with the preformed GPI [PMID: 8978684].

GO terms

Biological Process

GO:0016255 attachment of GPI anchor to protein

Molecular Function

GO:0003923 GPI-anchor transamidase activity

Cellular Component

GO:0042765 GPI-anchor transamidase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.