UDP-glucose 6-dehydrogenase, eukaryotic type (IPR028356)

Short name: UDPglc_DH_euk

Overlapping homologous superfamilies

Family relationships


UDP-glucose 6-dehydrogenase is involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), a critical precursor for glycan synthesis. In vertebrates it is involved in the biosynthesis of matrix glycosaminoglycans (hyaluronan, chondroitin sulfate, and heparan sulfan) which play significant roles in signaling, inflammation, morphogenesis, cancer growth and matrix organisation [PMID: 21502315]. In plants, it provides nucleotide sugars for cell-wall polymers [PMID: 8938413]. Proteins in this entry include human UDP-glucose 6-dehydrogenase [PMID: 21502315, PMID: 22123821].

This entry represents the UDP-glucose 6-dehydrogenase mainly from eukaryotes. However, subsets of bacterial proteins can be found in this entry. Most of the bacterial type of the UDP-glucose 6-dehydrogenase can be found in IPR028357.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003979 UDP-glucose 6-dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.