Estrogen receptor beta/gamma (IPR028355)

Short name: ER-beta/gamma

Overlapping homologous superfamilies


Family relationships


There are three distinct estrogen receptor (ER) subtypes: ER-alpha, ER-beta, and a third type (ER-gamma) identified in teleost fish [PMID: 11005855]. This entry represents the subtypes beta and gamma.

ER-beta binds estrogens and activates expression of reporter genes containing estrogen response element (ERE). ER-beta differs from ER-alpha in its ligand binding affinities to both natural and synthetic estrogens, tissue distributions, and transactivation properties [PMID: 9048584, PMID: 9278514]. The presence of different ER explains the seemingly contradictory actions of estrogens in certain target tissues, and illustrates the complexity of estrogenic action.


GO terms

Biological Process

GO:0030520 intracellular estrogen receptor signaling pathway

Molecular Function

GO:0030284 estrogen receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.