Family

HAUS augmin-like complex subunit 2 (IPR028346)

Short name: HAUS2

Overlapping homologous superfamilies

None.

Family relationships

Description

This entry represents HAUS augmin-like complex subunit 2 from animals (HAUS2) and plants (AUG2) [PMID: 19427217, PMID: 22505726].

The HAUS (Homologous to AUgmin Subunits) individual subunits have been designated HAUS1 to HAUS8 [PMID: 19427217]. In animals, HAUS augmin-like complex subunit 2 is a component of the HAUS augmin-like complex, which localises to the centrosomes and interacts with the gamma-tubulin ring complex (gamma-TuRC) [PMID: 14654843]. The interaction between augmin and gamm-TuRC is important for spindle microtubule generation and affects the mitotic progression and cytokinesis [PMID: 19369198]. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis [PMID: 19369198]. The HAUS augmin-like complex subunit 2 was previously known as centrosomal protein of 27kDa (Cep27).

In plants, the augmin complex contains 8 subunits, including two plant-specific subunits [PMID: 22505726]. Despite lacking cetrosomes, the augmin complex in plants plays an important part in gamma-tubulin-dependent MT nucleation and the assembly of microtubule arrays during mitosis [PMID: 22505726].

GO terms

Biological Process

GO:0031023 microtubule organizing center organization
GO:0051225 spindle assembly

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam