Folate transporter 1 (IPR028339)

Short name: RFC

Overlapping homologous superfamilies


Family relationships


Folate transporter 1 (also known as reduced folate carrier, RFC, or SLC19A1) belongs to the RFC transporter family (IPR002666). It is a transporter for the intake of folate, reduced folates and methotrexate [PMID: 7641195]. It has a function in folate homeostasis and thus in preventing diseases such as neural tube defects and other birth defects [PMID: 20683905]. Mutations in the SLC19A1 gene have been found to be correlated with various cancers and with variable response to methotrexate and related compounds for rheumatoid arthritis and cancer [PMID: 20811316].

GO terms

Biological Process

GO:0015884 folic acid transport
GO:0051958 methotrexate transport

Molecular Function

GO:0008518 folate:anion antiporter activity
GO:0015350 methotrexate transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.