Family

Folate transporter 1 (IPR028339)

Short name: RFC

Family relationships

Description

Folate transporter 1 (RFC, also known as SLC19A1) belongs to the reduced folate carrier (RFC) transporter family (IPR002666). It is a transporter for the intake of folate, reduced folates and methotrexate [PMID: 7641195]. It has a function in folate homeostasis and thus in preventing diseases such as neural tube defects and other birth defects [PMID: 20683905]. Mutations in the SLC19A1 gene have been found to be correlated with various cancers and with variable response to methotrexate and related compounds for rheumatoid arthritis and cancer [PMID: 20811316].

GO terms

Biological Process

GO:0015884 folic acid transport
GO:0051958 methotrexate transport

Molecular Function

GO:0008517 folic acid transmembrane transporter activity
GO:0015350 methotrexate transmembrane transporter activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PIRSF