Thiamine transporter 2 (IPR028337)

Short name: ThTr-2

Overlapping homologous superfamilies


Family relationships


Thiamine transporter 2 (ThTr-2, also known as SLC19A3) belongs to the reduced folate carrier (RFC) transporter family (IPR002666). However, it has no folate transport activity. It mediates high affinity thiamine uptake, propably via a proton anti-port mechanism [PMID: 11731220].

Mutations in ThTr-2 genes cause the thiamine-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disease characterised by megaloblastic anemia, diabetes mellitus, and sensorineural deafness [PMID: 10391221, PMID: 10874303].

GO terms

Biological Process

GO:0015888 thiamine transport

Molecular Function

GO:0015234 thiamine transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.