RelA-associated inhibitor (IPR028320)

Short name: iASPP

Overlapping homologous superfamilies


Family relationships



This entry represents RelA-associated inhibitor (also known as iASPP), which is a regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins [PMID: 10336463]. iASPP is an ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins that is homologous with ASPP1 and ASPP2 (IPR028319).

The ASPPs proteins regulate the apoptotic function of p53; iASPP inhibits p53, whereas ASPP1 and ASPP2 activates p53 [PMID: 17211478]. The p53 tumour suppressor gene is one of the most frequently mutated genes in human cancer that can suppress tumour growth through its ability to induce apoptosis or cell-cycle arrest. Therefore, the ASPP family of proteins may be a novel target for cancer therapy [PMID: 17211478].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0006351 transcription, DNA-templated

Molecular Function

GO:0008134 transcription factor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.