Apoptosis-stimulating of p53 protein 1 (IPR028319)

Short name: ASPP_1

Overlapping homologous superfamilies


Family relationships



This entry represents ASPP1 (apoptosis-stimulating of p53 protein).

In humans, p53 tumor suppressor is capable of suppressing tumour growth through its ability to induce apoptosis or cell-cycle arrest. The ASPPs proteins regulate the apoptotic function of p53; iASPP inhibits p53, whereas ASPP1 and ASPP2 activate p53 [PMID: 17211478, PMID: 11684014, PMID: 14729977]. The ASPP family of proteins may be a novel target for cancer therapy [PMID: 17211478].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0045786 negative regulation of cell cycle

Molecular Function

GO:0008134 transcription factor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.