Transcription factor E2F5 (IPR028316)

Short name: E2F5

Overlapping homologous superfamilies


Family relationships

  • E2F Family (IPR015633)
    • Transcription factor E2F5 (IPR028316)


E2F5 is a transcription activator that binds cooperatively with DP1 to E2F sites, which are present in the promoter of many genes whose products are involved in cell proliferation [PMID: 7542760]. E2F5 is a component of the DREAM (MuvB/DRM) complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [PMID: 17531812, PMID: 17671431].

GO terms

Biological Process

GO:0051726 regulation of cell cycle
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005667 transcription factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.