Transcription factor DP2 (IPR028314)

Short name: DP-2

Overlapping homologous superfamilies


Family relationships


E2F transcription factors regulate the expression of genes required for passage through the cell cycle. DP2 (also known as TFDP2) forms heterodimers with E2F family members and stimulates E2F-dependent transcription [PMID: 7784053, PMID: 7739537]. In humans, it is part of the DREAM (MuvB/DRM) complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [PMID: 17531812, PMID: 17671431].

GO terms

Biological Process

GO:0000278 mitotic cell cycle

Molecular Function

GO:0003712 transcription coregulator activity
GO:0008134 transcription factor binding

Cellular Component

GO:0005667 transcription factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.