Transcription factor E2F4 (IPR028312)

Short name: E2F4

Overlapping homologous superfamilies


Family relationships

  • E2F Family (IPR015633)
    • Transcription factor E2F4 (IPR028312)


E2F4 is a member of the E2F family of transcription factors. E2F4 binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication [PMID: 9364211]. In growth arrested cells, transcriptional activity by E2Fs is repressed by retinoblastoma (RB) proteins. E2F-4 can bind to RB and related proteins p130 to p107 [PMID: 8657117].

GO terms

Biological Process

GO:0000278 mitotic cell cycle
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.