Family

WASH1 (IPR028290)

Short name: WASH1

Family relationships

None.

Description

This entry represents members of the WASH1 family, which are components of the WASH complex that is present at the surface of endosomes and activates the Arp2/3-mediated F-actin polymerisation [PMID: 19922875]. WASH1 contains N-terminal WASH homology regions (also known as the WAHD domain, which covers the WHD1/EVH1 and WHD2 domains), a proline-rich region and a C-terminal WH2 domain [PMID: 19922874]. WASH1 localises to early endosomal subdomains through an essential interaction with FAM21 via its WHD1 domain and directly binds tubulin through its WHD2 domain, while linking to Arp2/3-mediated F-actin polymerisation via its C-terminal WH2 domain [PMID: 19922874].

GO terms

Biological Process

GO:0034314 Arp2/3 complex-mediated actin nucleation

Molecular Function

GO:0043014 alpha-tubulin binding

Cellular Component

GO:0071203 WASH complex
GO:0005769 early endosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER