WASH1 (IPR028290)

Short name: WASH1

Family relationships



This entry represents members of the WASH1 family, which are components of the WASH complex that is present at the surface of endosomes and activates the Arp2/3-mediated F-actin polymerisation [PMID: 19922875]. WASH1 contains N-terminal WASH homology regions (also known as the WAHD domain, which covers the WHD1/EVH1 and WHD2 domains), a proline-rich region and a C-terminal WH2 domain [PMID: 19922874]. WASH1 localises to early endosomal subdomains through an essential interaction with FAM21 via its WHD1 domain and directly binds tubulin through its WHD2 domain, while linking to Arp2/3-mediated F-actin polymerisation via its C-terminal WH2 domain [PMID: 19922874].

GO terms

Biological Process

GO:0034314 Arp2/3 complex-mediated actin nucleation

Molecular Function

GO:0043014 alpha-tubulin binding

Cellular Component

GO:0071203 WASH complex
GO:0005769 early endosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.