SCAR/WAVE family (IPR028288)

Short name: SCAR/WAVE_fam

Overlapping homologous superfamilies


Family relationships



This entry represents the SCAR/WAVE family. Members in this family include Wiskott-Aldrich syndrome protein family members 1-3 (WAVE 1-3), protein SCAR 1-4, protein WAVE5 and SCAR-like proteins.

SCAR/WAVE family members are downstream effector molecules receiving information from multiple signalling pathways and responding by promoting the actin nucleating activity of the ubiquitous Arp2/3 complex [PMID: 21107423]. They are part of the WAVE complex that regulates lamellipodia formation in animals and maintains cell shape in plants [PMID: 21107423, PMID: 23802001].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005856 cytoskeleton

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.