Domain

WASH complex subunit 7, central domain (IPR028282)

Short name: WASH-7_central

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the central, conserved region of WASH complex subunit 7 (WASH7), also known as subunit 4 or KIAA1033 [PMID: 19922875]. The WASH complex is present at the surface of endosomes and recruits and activates the Arp2/3 complex to induce mediated actin nucleation. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting [PMID: 19922875, PMID: 20888769].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam