RNA guanine-N7 methyltransferase activating subunit (IPR028271)

Short name: RAMAC

Overlapping homologous superfamilies


Family relationships



This entry represents RNA guanine-N7 methyltransferase activating subunit (RAMAC; also known as RNMT-activating mini protein, RAM), which is an essential component of the mRNA-capping methyltransferase RNMT:RAMAC complex required for mRNA cap methylation [PMID: 22099306, PMID: 27422871]. RAM consists of an N-terminal RNMT-activating domain and a C-terminal RNA-binding domain [PMID: 22099306].

In eukaryotes, the 7-methylguanosine cap added to the 5' end of mRNA is required for efficient gene expression. In mammals, methylation of the guanosine cap requires RNMT (RNA guanine-7 methyltransferase) [PMID: 22099306]. The interaction between RNMT and RAM enhances the mRNA binding capacity and cap methyltransferase activity [PMID: 22099306].

GO terms

Biological Process

GO:0106005 RNA 5'-cap (guanine-N7)-methylation

Molecular Function

GO:0003723 RNA binding

Cellular Component

GO:0005845 mRNA cap binding complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.